IL-4 and IL-17 Are Required for House Dust Mite-Driven Airway Hyperresponsiveness in Autoimmune Diabetes-Prone Non-Obese Diabetic Mice
نویسندگان
چکیده
Allergic asthma is characterized by airway inflammation with a Th2-type cytokine profile, hyper-IgE production, mucus hypersecretion, and hyperreactivity (AHR). It increasingly recognized that heterogeneous disease implicating complex immune mechanisms resulting in distinct endotypes observed patients. In this study, we showed non-obese diabetic (NOD) mice, which spontaneously develop autoimmune diabetes, undergo more severe allergic AHR than pro-Th2 BALB/c mice upon house dust mite (HDM) sensitization challenge. The use of IL-4-deficient NOD the vivo neutralization IL-17 demonstrated both IL-4 are responsible exacerbated mice. Overall, our findings indicate diabetes-prone might become useful as new HDM-induced model to elucidate dysimmune involving Th2 Th17 responses could better mimic some asthmatic endoytpes.
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2021
ISSN: ['1664-3224']
DOI: https://doi.org/10.3389/fimmu.2020.595003